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Received Jan 8; Accepted Aug This article has been cited by other articles in PMC.
Abstract Background The aim of this retrospective study was to evaluate the stability of spinal metastases in gynecologic cancer patients pts on the basis of a validated scoring system after radiotherapy RTto define prognostic factors for stability and to calculate survival.
Methods Fourty-four women with gynecologic malignancies and spinal bone metastases were treated at our department between January and January Additionally prognostic factors for stability, overall survival, and bone survival time between first day of RT of bone metastases and death from any cause were calculated.
Conclusions RT is capable of improving stability of osteolytic spinal metastases from gynecologic cancer by facilitating re-ossification in survivors. KPS may be a predictor for response.
Pts who received ChT prior to RT may require additional bone supportive treatment to overcome bone remodeling imbalance. Survival in women with bone metastases from gynecologic cancer remains poor.
Bone metastases, Spine, Gynecologic malignancies, Stability, Radiotherapy Introduction Bone metastases are a rare occurrence in gynecologic malignancies and in the majority of cases associated with a poor prognosis [ 1 — 8 ].
Patients pts are usually treated with a palliative intention to reduce pain and to preserve functionality. Treatment is usually multimodal and interdisciplinary. One of the main therapy modalities for bone metastases is radiotherapy RT.
Most frequently patients are treated for pain, but existing or impending instability, neurologic symptoms due to spinal cord compression and post-surgical RT are common indications as well [ 410 ].
On the one hand disability from pathologic fractures is risked if the vertebral column is not sufficiently stabilized, and on the other hand the usually prescribed surgical corsets add a significant immobilization to the already existing pain. However, mobilization and adequate exercises are of high importance for this subgroup of palliative pts regarding QoL [ 11 ] and reduction of the time of hospitalization.
Recently we reported on pts with lung cancer in which a significant response towards RT in terms of stability of bone metastases was shown [ 12 ].
The purpose of this analysis was to evaluate gynecologic cancer pts with spinal bone metastases treated at our department with a special focus on bone stability after RT, on prognostic factors for stability and on survival.
Methods Fourty-four women with thoracic or lumbar spinal bone metastases from gynecologic malignancies were treated at the Department of Radiation Oncology at the University Hospital of Heidelberg between January and January Bone metastases had to be located in the thoracic or lumbar spine.
Preexisting CT scans were reviewed regarding stability of the osteolytic lesions using the Taneichi score [ 13 ].
In pts with more than one metastasis per vertebral body, the one with the worst Taneichi score was assessed. Accordingly, osteolytic metastases with subtypes A to C were classified as stable, and subtypes D to F were classified as unstable.
Median follow-up was 6.of Gynecologic Malignancies John C. Roeske, PhD Associate Professor The University of Chicago. Roeske – AAPM NTCP Analysis Gynecologic IMRT Patients Roeske et al.
Radiother Oncol ; Conventional Pelvic RT IMRT. Roeske – AAPM . Pelvic and paraaortic lymph node evaluation is a major component of the surgical staging procedure for several gynecologic malignancies, including endometrial and ovarian carcinoma .
Cervical cancer is clinically staged, but assessment of pelvic and paraaortic lymph nodes is performed with. Daratumumab with carfilzomib and dexamethasone was well tolerated and active in patients with lenalidomide-refractory relapsed multiple myeloma.
CONTINUING EDUCATION Oncologic Imaging in Gynecologic Malignancies* Neeta Pandit-Taskar, MD Nuclear Medicine Service, Department of Radiology, Memorial Sloan .
Epithelial ovarian cancer is the most common ovarian malignancy. CA, the glycoprotein defined by the antibody OC , is the most important clinical marker for the diagnosis, treatment and follow-up of epithelial ovarian cancer. A larger and more prospective analysis is required to fully establish an appropriate strategy for prophylaxis of VTE in gynecological malignancies, and our results should provide a better framework for designing such a study.